Neuromuscular paralysis induced in insect larvae by the proteinic venom of a parasitic wasp

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F12%3A00376139" target="_blank" >RIV/60077344:_____/12:00376139 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Neuromuscular paralysis induced in insect larvae by the proteinic venom of a parasitic wasp
Original language description
Larvae of the greater wax moth (Galleria mellonella), stung by a tiny 2.5 mm long Habrobracon hebetor wasp, become immobilised within a few minutes and remain completely paralysed for several weeks. Paralysed larvae are absolutely motionless, flaccid, without internal pressure, serving as a source of food for the parasite. The venom is a relatively large proteinic molecule, its size has been estimated by various authors from 17 to 73 kDa, and the largest fraction has been partly sequenced. The mode of action is generally ascribed to the inhibition of neuromuscular transmission. Purely myogenic systems driven by depolarisation potentials of the muscle or myocardium cells (heart, intestine) or junctional potencials of the sympathetic nerves (glands, excretory organs), remain intact and fully functional. Using recently invented, touch-free electrocardiographic (ECG) techniques, we found that the heartbeat of paralysed larvae was regulated by a purely myogenic mechanism with a pacemaker no
Czech name
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Czech description
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Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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