Differential allergen expression in three Tyrophagus putrescentiae strains inhabited by distinct microbiome

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027006%3A_____%2F19%3A00005551" target="_blank" >RIV/00027006:_____/19:00005551 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/abs/10.1111/all.13921?af=R" target="_blank" >https://onlinelibrary.wiley.com/doi/abs/10.1111/all.13921?af=R</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/all.13921" target="_blank" >10.1111/all.13921</a>

Result language
angličtina
Original language name
Differential allergen expression in three Tyrophagus putrescentiae strains inhabited by distinct microbiome
Original language description
The domestic mite, Tyrophagus putrescentiae, is a medically important, ubiquitous pest that commonly occurs in stored food and house dust, causing allergies. We analyzed the transcriptomes of three strains of T. putrescentiae, each harboring a different microbiome. These mite strains were analyzed at a level representative of a natural population using seven replicates. We found 78 transcripts belonging to 8 allergen groups known in T. putrescentiae (2, 3, 10, 13, 28, 34, 35 and 36) and identified 16 putative allergen groups previously unknown for this mite species (4, 5, 6, 7, 8, 11, 14, 16, 20, 24, 25, 27, 30, 31, 33 and 38). We documented polymorphism and differences in the expression level of these transcripts. Most importantly, the expression of several allergens (group 4, 7, 10, 11, 13, 20 and 36) was correlated with the presence of common intracellular bacterial symbionts, Wolbachia and Blattabacterium-like bacteria. The largest differences in allergen expression among the strains were found in allergen groups 2, 10, and 13 (known allergens) and groups 4 and 14 (putative allergens). We suggest that allergen production in T. putrescentiae may be affected by its microbiome composition.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10618 - Ecology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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