Essential oil and furanosesquiterpenes from myrrh oleo-gum resin: a breakthrough in mosquito vector management
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027006%3A_____%2F25%3A10177973" target="_blank" >RIV/00027006:_____/25:10177973 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/content/pdf/10.1007/s13659-024-00492-6.pdf" target="_blank" >https://link.springer.com/content/pdf/10.1007/s13659-024-00492-6.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s13659-024-00492-6" target="_blank" >10.1007/s13659-024-00492-6</a>
Alternative languages
Result language
angličtina
Original language name
Essential oil and furanosesquiterpenes from myrrh oleo-gum resin: a breakthrough in mosquito vector management
Original language description
Mosquitoes (Diptera: Culicidae) are vectors of various pathogens of public health concern and replacing conventional insecticides remains a challenge. In this regard, natural products represent valuable sources of potential insecticidal compounds, thus increasingly attracting research interest. Commiphora myrrha (T.Nees) Engl. (Burseraceae) is a medicinal plant whose oleo-gum resin is used in food, cosmetics, fragrances, and pharmaceuticals. Herein, the larvicidal potential of its essential oil (EO) was assessed on four mosquito species (Aedes albopictus Skuse, Aedes aegypti L., Anopheles gambiae Giles and Anopheles stephensi Liston), with LC50 values ranging from 4.42 to 16.80 mu g/mL. The bio-guided EO fractionation identified furanosesquiterpenes as the main larvicidal compounds. A GC-MS-driven untargeted metabolomic analysis revealed 32 affected metabolic pathways in treated larvae. The EO non-target toxicity on Daphnia magna Straus (LC50 = 4.51 mu L/L) and its cytotoxicity on a human kidney cell line (HEK293) (IC50 of 14.38 mu g/mL) were also assessed. This study shows the potential of plant products as innovative insecticidal agents and lays the groundwork for the possible exploitation of C. myrrha EO in sustainable approaches for mosquito management.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40106 - Agronomy, plant breeding and plant protection; (Agricultural biotechnology to be 4.4)
Result continuities
Project
<a href="/en/project/FW06010376" target="_blank" >FW06010376: Development of new plant protection products based on plant extracts</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
NATURAL PRODUCTS AND BIOPROSPECTING
ISSN
2192-2195
e-ISSN
2192-2209
Volume of the periodical
15
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
17
Pages from-to
12
UT code for WoS article
001400421500001
EID of the result in the Scopus database
2-s2.0-85217475258