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Effect of Pectin and Amidated Pectin on Cholesterol Homeostasis and Cecal Metabolism in Rats Fed a High-Cholesterol Diet

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F07%3A%230000472" target="_blank" >RIV/00027014:_____/07:#0000472 - isvavai.cz</a>

  • Alternative codes found

    RIV/67985904:_____/07:00089238 RIV/60461373:22330/07:00018355

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Effect of Pectin and Amidated Pectin on Cholesterol Homeostasis and Cecal Metabolism in Rats Fed a High-Cholesterol Diet

  • Original language description

    The effect of pectin and its hydrophobic derivatives on homeostasis of cholesterol and cecal metabolism in rats was investigated. Rats were fed a diet with fat and cholesterol. Experimental rats were fed diet containing pectin or pectinamide. Pectinamideof 30% of amidation increased serum HDL cholesterol and pectinamide of 53% of amidation decreased total serum cholesterol. Amidated pectins decreased hepatic concentrations of cholesterol and fat. The highest cecal concentrations of short-chain fatty acids (SCFA) were in rats fed a pectin diet. In other groups, cecal SCFA was lower. Both pectinamides increased fecal cholesterol concentration. Hepatic tissue of control and pectin-fed rats was infiltrated with lipids. Thus, hydrophobic amidated pectins altered cholesterol homeostasis in rats and might be considered as effective hypocholesterolemic agents.

  • Czech name

    Vliv pektinu a amidovaného pektinu na homeostázi cholesterolu a metabolismus slepého střeva u potkanů krmených dietou s vysokým obsahem cholesterolu

  • Czech description

    Byl zjišťován vliv pektinu a jeho hydrofobních derivátů na homeostázi cholesterolu a metabolismus slepého střeva u potkanů. Potkani byli krmeni dietou s tukem a cholesterolem, ostatní dietou obsahující pektin nebo pektinamid. Pektinamid s 30% amidací zvyšoval HDL cholesterol v séru. Při 53% amidaci se snižoval celkový cholesterol v séru Oba amidované pektiny snižovaly obsah cholesterolu a tuku v játrech. Nejvyšší obsah mastných kyselin s krátkým řetězcem ve slepém střevě byl u potkanů s pektinovou dietou, u ostatních byl nižší. Pektinamidy zvyšovaly cholesterol ve výkalech. Jaterní tkáň u potkanů kontrolních a krmených pektinem byla infiltrována lipidy. Tudíž hydrofobní amidované pektiny mění homeostázi cholesterolu u potkanů a lze je považovat za účinný hypocholesterolemický prostředek.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    GH - Nutrition of farm animals

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GA525%2F03%2F0358" target="_blank" >GA525/03/0358: Preparation, structural characterization and biological effects of derivates of pectin</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2007

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Physiological Research

  • ISSN

    0862-8408

  • e-ISSN

  • Volume of the periodical

    56

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    10

  • Pages from-to

    433-442

  • UT code for WoS article

  • EID of the result in the Scopus database