Effect of antioestrogens on proliferation, differentiation and telomerase activity of pig granulosa cells in vitro

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F10%3A%230001285" target="_blank" >RIV/00027014:_____/10:#0001285 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Effect of antioestrogens on proliferation, differentiation and telomerase activity of pig granulosa cells in vitro

Original language description

The aim of the work was to study the effect of oestrogen receptor (ER) inhibitors (ICI 164.384; ICI and cyclofenil; CF) on proliferation, oestradiol synthesis, aromatase expression and telomerase activity (TA) of pig granulosa cells (GC). Antioestrogensapplied individually and in a combination significantly (P<0.01) decreased proliferative potential of LF-GC. Antioestrogens applied in a combination increased (P<0.05) 17-? oestradiol synthesis in small and large follicle GC. Antioestrogens applied individually and in a combination caused an increase (P<0.01) of aromatase gene expression in FSH-stimulated conditions as well as in basic conditions. Moreover, antioestrogens increased (P<0.05) TA in basic and in FSH-stimulated conditions. The results indicate the involvement of ER ? and ? in the control of proliferation, differentiation and telomerase activity in pig GC. Furthermore, TA does not have to be linked only to pig GC proliferation but may also be involved in the differentiation

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/GA523%2F05%2F2062" target="_blank" >GA523/05/2062: Developmental potential and molecular differentiation of pig follicular granulosa cells in vitro</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Animal and Feed Sciences

ISSN

1230-1388

e-ISSN

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Volume of the periodical

19

Issue of the periodical within the volume

4

Country of publishing house

PL - POLAND

Number of pages

13

Pages from-to

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UT code for WoS article

000286028700007

EID of the result in the Scopus database

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