Faecal Output of Sterols and Fat in Rats Fed Amidated Cellulose

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F13%3A%230001953" target="_blank" >RIV/00027014:_____/13:#0001953 - isvavai.cz</a>
Result on the web
<a href="http://www.vuzv.cz/sites/File/_privat/13182.pdf" target="_blank" >http://www.vuzv.cz/sites/File/_privat/13182.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Faecal Output of Sterols and Fat in Rats Fed Amidated Cellulose
Original language description
Hypercholesterolemia and obesity belong to the main risk factors of coronary heart disease, which is the leading cause of deaths worldwide. Several methods for the treatment of hypercholesterolemia exist, mainly fat restriction, the use of inhibitors of3-hydroxy-3-methylglutaryl-CoA reductase (statins), and sequestrans that bind bile acids in the small intestine and interrupt their enterohepatic circulation (Stedronsky, 1994). Increased conversion of cholesterol to bile acids in the liver compensates for the loss of bile acids in faeces, which results in reduction of cholesterolemia. An alternative to bile acid sequestrants are sorbents of sterols prepared by amidation of polysaccharides. In our recent study, the hypocholesterolemic effect of octadecylpectinamide was examined in rats fed diets containing cholesterol at 10 g for kg (Marounek et al., 2013). Amidated pectin supplied at 20, 40 and 60g for kg significantly decreased serum cholesterol from 3.32 (control) to 1.23 mikromol fo
Czech name
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Czech description
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Project
<a href="/en/project/GAP503%2F11%2F2479" target="_blank" >GAP503/11/2479: Inhibition of intestinal absorption of sterols by hydrophobically modified polysaccharides</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Proceedings of the 9th International Conference on Polysaccharides-Glycoscience
ISBN
978-80-86238-58-6
ISSN
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e-ISSN
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Number of pages
3
Pages from-to
159-161
Publisher name
Czech Chemical Society, Novotneho Lavka 5, Prague, Czech Republic
Place of publication
Prague
Event location
Prague
Event date
Nov 6, 2013
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
000341216900039

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