Comparative study of the hypocholesterolemic and hypolipidemic activity of alginate and amidated alginate in rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F17%3AN0000180" target="_blank" >RIV/00027014:_____/17:N0000180 - isvavai.cz</a>

Alternative codes found

RIV/60460709:41210/17:74116 RIV/60460709:41340/17:75637

Result on the web

<a href="https://vuzv.cz/_privat/17177.pdf" target="_blank" >https://vuzv.cz/_privat/17177.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijbiomac.2017.07.077" target="_blank" >10.1016/j.ijbiomac.2017.07.077</a>

Result language

angličtina

Original language name

Comparative study of the hypocholesterolemic and hypolipidemic activity of alginate and amidated alginate in rats

Original language description

Alginate is a copolymer of beta-D-mannuronate and alfa-L-guluronate, which are present in the cell wall of brown algae. The hypocholesterolemic and hypolipidemic activities of alginate and its derivative,which is prepared by a reaction with octadecylamine, were compared in rats fed diets containing cholesterol and palm fat at 10 and 50 g/kg, respectively. Amidated alginate at 20 g/kg significantly decreased serum cholesterol from 2.93 to 2.00 mikromol/mL, serum triacylglycerols from 1.66 to 0.92 mikromol/mL, hepatic cholesterol from 17.5 to 5.9 mikromol/g, and total hepatic lipids from 67.4 to 51.7 mg/g. Alginate at 20 g/kg significantly reduced hepatic cholesterol to 13.1 mikromol/g, but did not influence serum cholesterol, triacyl-glycerols, and total hepatic lipids. Amidated alginate significantly increased the faecal concentrations of neutral sterols from 98.7 to 122.4 mikromol/g DM, but decreased faecal concentration of bile acids from 19.4 to 14.0 mikromol/g DM. In samples of intestinal contents, taurine-conjugated bile acids dominated glycineconjugates. The supplementation of diets with cholesterol significantly increased the expression of hepatic cholesterol 7 alfa-hydroxylase, especially in rats that received cholesterol without alginate or amidatedalginate. In conclusion, amidated alginate is an effective hypocholesterolemic agent that is more efficient than its parent polysaccharide.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Biological Macromolecules

ISSN

0141-8130

e-ISSN

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Volume of the periodical

105

Issue of the periodical within the volume

není

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

5

Pages from-to

620-624

UT code for WoS article

000414882900069

EID of the result in the Scopus database

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