Effect of amidated alginate on faecal lipids, serum and hepatic cholesterol in rats fed diets supplemented with fat and cholesterol

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F19%3AN0000003" target="_blank" >RIV/00027014:_____/19:N0000003 - isvavai.cz</a>

Result on the web

<a href="https://vuzv.cz/_privat/19002.pdf" target="_blank" >https://vuzv.cz/_privat/19002.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijbiomac.2018.10.180" target="_blank" >10.1016/j.ijbiomac.2018.10.180</a>

Result language

angličtina

Original language name

Effect of amidated alginate on faecal lipids, serum and hepatic cholesterol in rats fed diets supplemented with fat and cholesterol

Original language description

The effect of octadecylamide of alginic acid on serum and hepatic cholesterol, and the faecal output of fat and sterols was examined in female rats fed diets containing cholesterol and palm fat at 10 and 50 g kg−1, respectively. Cholesterol supplementation significantly increased serum and hepatic cholesterol concentrations, and faecal output of cholesterol and coprostanol. Cholesterol and amidated alginate supplementations changed the profile of fatty acids in the faeces. Cholesterol increased molar percentages of saturated fatty acids and amidated alginate reversed this effect. Amidated alginate, supplied at 10, 20 and 40 g kg−1, significantly decreased serum cholesterol from 2.82 to 2.00, 1.95, and 1.63 μmol mL−1, respectively, and significantly decreased hepatic cholesterol from 13.8 to 9.33, 7.81 and 6.3 μmol g−1, respectively. Amidated alginate increased the faecal output of fat and neutral sterols in a dose-dependent manner. In contrast, the output of bile acids was significantly decreased. The faecal outputs of fat and serum cholesterol were negatively correlated. At the highest concentration tested, amidated alginate significantly reduced the serum concentration of triacylglycerols. It can be concluded that amidated alginate is an effective cholesterol-lowering agent and sorbent of dietary fat.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Biological Macromolecules

ISSN

0141-8130

e-ISSN

—

Volume of the periodical

122

Issue of the periodical within the volume

n

Country of publishing house

NO - NORWAY

Number of pages

4

Pages from-to

499-502

UT code for WoS article

000456226700056

EID of the result in the Scopus database

2-s2.0-85055989437