Preparation of phospholipid delivery systems by CO2 assisted spray nebulisation.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027022%3A_____%2F17%3AN0000005" target="_blank" >RIV/00027022:_____/17:N0000005 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Preparation of phospholipid delivery systems by CO2 assisted spray nebulisation.

Original language description

Beran M, Drahorad J, Vltavsky O, Urban M, Molik P, Sova J. Preparation of phospholipid delivery systems by CO2 assisted spray nebulisation. Poster-short lecture. International Conference on Materials Science&Technology. 01-03 March 2017, Allabahad, India Engineering efforts of researches of the Food research institute Prague and the Czech Technical University in spray drying technologies led to introduction of the Spray Nebulisation Drying (SND) process and a pilot-plant demonstrator ATOMIZER. The equipment combines the spray drying technology, when the liquid to be dried is atomized by a rotary disk atomizer, with carbon dioxide assisted nebulization process in an original way. A solution, emulsion or suspension is saturated by carbon dioxide at pressure 40-80 bar before the drying process. The atomization process takes place in two steps. In the first step, primary droplets are produced at the outlet of the rotary atomizer of special construction. In the second step, the primary droplets are divided in secondary droplets by the CO2 expansion from the inside of primary droplets. The secondary droplets, usually in the form of microbubbles, are rapidly dried by warm air stream at temperatures up to 60⁰C and solid particles are formed in a drying chamber. Powder particles are separated from the drying air stream in a powder separator. The SND technology combines the advantages of high production rate with gentle drying at low temperatures and reduced particle size of the product. A wide range of application forms - low density particles, composite particles, sterically stabilized liposomes, phytosomes, microencapsulated particles or microbial cells, solid dispersions, dried single and multiple emulsions, nano- and microfibers and other - can be produced by this process. The main objectives of this study was to develop a new simple and cheap method of preparation of phospholipid delivery systems for selected nutraceuticals. Phospholipid complexes of glutathione, EGCG, and curcumin, stabilised by chitosan, have been prepared. Stability of the phospholipid complexes have been tested at acidic (pH3) and slightly alkaline (pH8) conditions.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

40401 - Agricultural biotechnology and food biotechnology

Project

<a href="/en/project/TH01020905" target="_blank" >TH01020905: Progressive nanotechnologies for food and medical applications.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů