Antimicrobial polyhydroxybutyrate submicron fiber mat loaded with extract of Hypericum perforatum

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027022%3A_____%2F21%3AN0000001" target="_blank" >RIV/00027022:_____/21:N0000001 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Antimicrobial polyhydroxybutyrate submicron fiber mat loaded with extract of Hypericum perforatum

Original language description

Milos Beran, Ales Horna, Viktor Vorisek, Eliska Berkova, Radka Korinkova, Vojtech Trousil, Marketa Hrubanova. Invited lecture: Antimicrobial polyhydroxybutyrate submicron fiber mat loaded with extract of Hypericum perforatum. The European Advanced Materials Congress. 23-25 August 2021, Stockholm, Sweden. The aim of this work was to prepare a new biodegradable polyhydroxybutyrate submicron fiber mat loaded with Hypericum perforatum hypericin rich raw extract by centrifugal spinning technology, an alternative approach to fabricate nanofibers or microfibers from solutions at high speed and low cost. Hypericins in methanol/aceton extract of H. perforatum were determined by UHPLC-MS/MS and HPLC/PDA methods. Pure PHB and the H. perforatum extract enriched PHB submicron fiber mats were prepared using a pilot plant demonstrator for the centrifugal spinning technology and characterized by SEM. Singlet oxygen production was quantified by the 1,3-diphenylisobenzofuran method in hexan. The results proved a significant production of singlet oxygen by the prepared submicron fiber mat. We have also found a very significant antibacterial activity against Escherichia coli CCM 5417 bacterial strain by a method in accordance with JIS Z 2801 / ISO 22196 tests. Determination of antiviral activities of the submicron fiber mats with H. perforatum extract against enveloped virus is in progress. The H. perforatum extract enriched PHB submicron fiber mats showed potential in development of self-cleaning and antimicrobial air filters.

Czech name

—

Czech description

—

Type

O - Miscellaneous

CEP classification

—

OECD FORD branch

21001 - Nano-materials (production and properties)

Project

<a href="/en/project/TH03020466" target="_blank" >TH03020466: Innovated equipment and technology for industrial nanofiber production by solution blow spinning.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů