Soft and hard polymeric foams for tissue engineering

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027022%3A_____%2F23%3AN0000086" target="_blank" >RIV/00027022:_____/23:N0000086 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Soft and hard polymeric foams for tissue engineering

Original language description

In this work, two different types of foam based biodegradable scaffolds for bone and soft tissue engineering with a fully interconnected porous network have been prepared: 1) soft polymeric foams with hierarchical micro-macro porous structure reinforced by addition of nanoparticular inorganic reinforcement fillers; 2) 3D printed polymeric scaffolds. Soft foams with micro-macro porous hierarchical structure have been prepared by freeze-drying of solutions of polylactide (PLA), polycaprolactone (PCL) or their mixtures in dioxane. The foams prepared by freeze-drying had interconnected porous aerogel characteristics. The hierarchical structure with bimodal micro-macro pore size distribution was obtained after addition of NaCl porogen to the solutions before freeze-drying and leaching the crystals from the freeze-dried foams with demineralised water. Additive manufacturing techniques enable to fabricate polymeric scaffolds with tailored architecture, to control its functionality and to optimize the parameters of the scaffolds and create structures with desired characteristics like controllable biodegradability and mechanical stability along with a precise pore size and high permeability for purposes of osteoinduction, osseointegration and angiogenesis. Ten samples of the hard foams with different inner geometries were printed from natural PLA. To verify their biocompatibility, the scaffolds were seeded with human osteoblast-like SAOS-2 cells. Morphology of the cells attached to the scaffolds was evaluated and their viability was verified by a metabolic test.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

30404 - Biomaterials (as related to medical implants, devices, sensors)

Project

<a href="/en/project/NU20-08-00208" target="_blank" >NU20-08-00208: Novel vascularized stem-cell based constructs for soft and hard tissue engineering</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů