Aryl hydrocarbon receptor-mesiated activity of mutagenic polycyclic aromatic hydrocarbons determined using in vitro reporter gene assay
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F01%3A80000021" target="_blank" >RIV/00027162:_____/01:80000021 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Aryl hydrocarbon receptor-mesiated activity of mutagenic polycyclic aromatic hydrocarbons determined using in vitro reporter gene assay
Original language description
AhR activity of 30 PAHs was determined in CALUX assay using 6 and 24 h exposure times. The highest relative potencies (IEFs) were observed for benzofluoranthenes and dibenzoanthracenes and dibenzofluoranthenes. The 6 h exposure led to significantly higher AhR-mediated activities than the 24 h exposure, probably due to rate of PAH metabolism. Comparison of mutagenicity and AhR activity with environmental concentrations were performed Our data indicated, that AhR-mediated activity of PAHs, including highly mutagenic compounds, significantly contribute to the overall toxicity of PAH contaminated samples.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
DN - Environmental impact on health
OECD FORD branch
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Result continuities
Project
<a href="/en/project/QC0194" target="_blank" >QC0194: Biochemical markers of dioxin-like toxicity and further specific effects of xenobiotics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2001
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mutation Research
ISSN
1383-5718
e-ISSN
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Volume of the periodical
497
Issue of the periodical within the volume
1-2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
14
Pages from-to
49-62
UT code for WoS article
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EID of the result in the Scopus database
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