Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F11%3A00054233" target="_blank" >RIV/00216224:14310/11:00054233 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/11:00368757 RIV/68378041:_____/11:00368757 RIV/00027162:_____/11:#0000814

Result on the web

<a href="http://dx.doi.org/10.1016/j.toxlet.2011.07.011" target="_blank" >http://dx.doi.org/10.1016/j.toxlet.2011.07.011</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.toxlet.2011.07.011" target="_blank" >10.1016/j.toxlet.2011.07.011</a>

Result language

angličtina

Original language name

Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands

Original language description

Carcinogenic polycyclic aromatic hydrocarbons (PAHs) are known as efficient mutagens and ligands of the aryl hydrocarbon receptor (AhR), which has been suggested to play an important role in prostate carcinogenesis. In order to evaluate the complex relationship between the genotoxicity and the AhR-mediated activity of PAHs in prostate cells, we explored global changes in gene expression in LNCaP cells by microarray analysis. We identified 112 genes that were differentially expressed in cells treated for24 h with BaP, TCDD or both compounds. Our data indicated that the impacts of BaP and TCDD on transcriptome of LNCaP cells significantly overlap, since over 64 % of significantly up-regulated genes and 47% of downregulated genes were similarly affectedby both AhR ligands. The AhR ligand-induced Wnt5a upregulation, together with other observed alterations of gene expression, may further contribute to enhanced cell plasticity of prostate carcinoma cells.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

TOXICOLOGY LETTERS

ISSN

0378-4274

e-ISSN

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Volume of the periodical

206

Issue of the periodical within the volume

2

Country of publishing house

IE - IRELAND

Number of pages

11

Pages from-to

178-188

UT code for WoS article

000295298800010

EID of the result in the Scopus database

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