Attenuated aroA Salmonella enterica serovar Typhimurium does not induce inflammatory response and early protection of gnotobiotic pigs against parental virulent LT2 strain

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F06%3A%230000072" target="_blank" >RIV/00027162:_____/06:#0000072 - isvavai.cz</a>

Alternative codes found

RIV/61388971:_____/06:00099636

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Attenuated aroA Salmonella enterica serovar Typhimurium does not induce inflammatory response and early protection of gnotobiotic pigs against parental virulent LT2 strain

Original language description

Cytokine and inflammatory response against virulent LT2 strain and its attenuated aroA deletion mutant of Salmonella enterica serovar Typhimurium were compared in gnotobiotic pigs. Contrary to the parental strain, the auxotrofic mutant did not induce IL-1beta, IL-18, TNF-alpha, and IFN-gamma in the ileum and plasma 24h after the infection, did not cause pathological changes in ileal epithelium and mesenteric lymph nodes or immunoreactivity of gp91 phox and peroxynitrite and was not immunostained for GroEL stress protein. The absence of induction of proinflammatory cytokines may be a reason why aroA mutant was unable to elicit any inflammatory response and protect pigs against challenge with virulent LT2 strain administered 24h later.

Czech name

Atenuovaný kmen Salmonella enterica serovar Typhimurium aroA neindukuje prozánětlivou odpověď a nechrání gnotobiotická selata proti časné infekci virulentním kmenem LT2

Czech description

V této práci byla porovnána cytokinová odpověď gnotobiotických selat na infekci divokým kmenem S. Typhimurium LT2 a jeho izogenním mutantem aroA. Na rozdíl od divokého kmene, aroA mutant nestimuloval produkci IL-1beta, IL-18, TNF alfa a IFN gamma ve střevě i séru 24 hodin po infekci. Po infekci aroA mutantem nebyly pozorovány ani žádné patologické změny na sliznici střeva, ani produkce gp91 phox oxidázy nebo peroxynitrátů. Absence zánětlivé reakce po infekci aroA mutantem zřejmě korelovala s jeho neschopností chránit gnotobiotická selata proti infekci divokým kmenem.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GJ - Diseases and animal vermin, veterinary medicine

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2006

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Vaccine

ISSN

0264-410X

e-ISSN

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Volume of the periodical

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Issue of the periodical within the volume

20

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

20

UT code for WoS article

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EID of the result in the Scopus database

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