Sperm fluorescence in situ hybridization study of meiotic segregation and an interchromosomal effect in carriers of t(11;18)
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F08%3A%230000350" target="_blank" >RIV/00027162:_____/08:#0000350 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Sperm fluorescence in situ hybridization study of meiotic segregation and an interchromosomal effect in carriers of t(11;18)
Original language description
Balanced translocations are associated with infertility, spontaneous abortions and birth defects. We report the analysis, by multicolour fluorescence in situ hybridization (FISH), of meiotic segregation and aneuploidy of chromosomes X, Y, 7, 8 and 21 insperm from three carriers of two different t(11;18). The prevalence of alternate segregation followed by adjacent 1, adjacent 2, and 3:1 was observed in all three patients. Two carriers of the same translocation differed only in the frequency of adjacent2 segregation. The carrier of the other translocation showed significantly higher frequency of alternate and less adjacent 1 and 3:1 segregation products. An increased frequency of XY, YY and diploid sperm was detected in the group of translocation carriers compared to controls. This was caused by elevated frequencies of disomy and diploidy in two of our carriers. The incidence of abnormal gametes varies in the individual carriers even if the same chromosomes are included in the translo
Czech name
Meiotická segregace a interchromosomální efekt u nositelů translokace t(11;18) studované metodou Sperm FISH
Czech description
Balancované translokace jsou spojeny s infertilitou, spontánními aborty a vrozenými defekty. Referujeme o analýze meiotické segregace a aneuploidií chromosomů X, Y, 7, 8 a 21 ve spermiích 3 nositelů 2 různých t(11;18) mnohobarevnou FISH. Nejčastěji bylapozorována alternativní segregace a dále segregace typu 1, typu 2 a 3:1. Nositelé stejné translokace se lišili ve frekvenci segregace typu 2. Nositel odlišné translokace vykazoval více produktů alternativní segregace a méně typu 1 a 3:1. Ve srovnání s kontrolami byla pozorována zvýšená frekvence XY, YY a diploidních spermií, což bylo způsobeno jejich vysokou frekvencí u dvou z nositelů translokací. Incidence abnormálních gamet se liší u jednotlivých nositelů translokací, i když jsou u nich v translokacizahrnuty stejné chromosomy.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Human Reproduction
ISSN
0268-1161
e-ISSN
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Volume of the periodical
23
Issue of the periodical within the volume
3
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
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UT code for WoS article
000253746900017
EID of the result in the Scopus database
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