aroA and aroD mutations influence biofilm formation in Salmonella Enteritidis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F09%3A%230000502" target="_blank" >RIV/00027162:_____/09:#0000502 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
aroA and aroD mutations influence biofilm formation in Salmonella Enteritidis
Original language description
aro mutants of Salmonella enterica are frequently used as live vaccines for oral vaccination of domestic animals. Interestingly, besides their auxotrophy, they appear to be of reduced resistance to the components of the innate immune response due to a defect in outer membrane and/or cell wall integrity. We were interested in the ability of aroA and aroD mutants of S. Enteritidis to adhere to solid surfaces. aroA and aroD mutants did not adhere to solid surfaces although they bind Congo red and producedD-mannose and D-glucose capsular polysaccharides in the same amount as the wild type strain. However the aro mutants exhibited a decreased production of cellulose, N-acetyl-D-glucosamine or N-acetylneuraminic acid containing capsular polysaccharide and fimbriae which explains their inability to form biofilms. aroA and aroD containing plasmids complemented all the defects of the aro mutants. Beside its attenuation for host, the loss of ability to form biofilm is additional characteristic
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Project
<a href="/en/project/LC06030" target="_blank" >LC06030: Biomolecular centre</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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