Comparative analysis of Salmonella enterica serovar Enteritidis mutants with a vaccine potential
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F09%3A%230000531" target="_blank" >RIV/00027162:_____/09:#0000531 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Comparative analysis of Salmonella enterica serovar Enteritidis mutants with a vaccine potential
Original language description
If any new live Salmonella vaccine is introduced in the future, it is quite probable that detailed characterisation of attenuation will be required. In this study we compared 34 isogenic mutants of S. Enteritidis in aroA, aroD, galE, ssrA, sseA, phoP, rpoS, ompR, htrA, clpP, lon, rfaL, rfaG, rfaC, hfq, sodCI, hilA, sipA, avrA, sopB, sopA, sopE, sifA, shdA, fliC, fur, relA, spoT, relA-spoT, misL, rmbA, STM4258, STM4259 and spvBC genes for their resistance to stresses and for their virulence and immunogenicity in Balb/C mice. We found that the cold and bile resistances did not correlate with the resistances to other stresses. Resistance to acid pH, heat, polymyxin and serum correlated with each other and also with the attenuation. When the residual virulence and immunogenicity were both considered, mutants in htrA, ompR, aroA, aroD and lon performed the best in mice. Furthermore, when a comparison of polymyxin and serum sensitive mutants was performed, the serum sensitive mutants were mo
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
GJ - Diseases and animal vermin, veterinary medicine
OECD FORD branch
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Result continuities
Project
<a href="/en/project/QH91238" target="_blank" >QH91238: Vaccination and protection of poultry against Salmonella infection</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Vaccine
ISSN
0264-410X
e-ISSN
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Volume of the periodical
27
Issue of the periodical within the volume
38
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
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UT code for WoS article
000269071900018
EID of the result in the Scopus database
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