Lyophilised liposome-based formulations of alpha-tocopheryl succinate: preparation and physico-chemical characterisation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F10%3A%230000617" target="_blank" >RIV/00027162:_____/10:#0000617 - isvavai.cz</a>

Alternative codes found

RIV/86652036:_____/10:00349342

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Lyophilised liposome-based formulations of alpha-tocopheryl succinate: preparation and physico-chemical characterisation

Original language description

alpha-Tocopheryl succinate (TOS) exerts selective toxicity to the cancer cells and anticancer activity in vivo. Yet, no suitable formulation of TOS for medical application has been reported. We developed and characterised a stable lyophilised liposome-based TOS formulation. TOS (15 mol%) was incorporated into large oligolamellar vesicles composed of soy phosphatidylcholine by the method of lipid film hydration followed by extrusion through polycarbonate filters. Stabilised liposomal formulation was prepared by lyophilisation in the presence of sucrose (molar ratio lipid/sucrose, 1:5). The size distribution of the liposomes (130-140 nm, polydispersity index 0.14) as well as the stable lipid and TOS contents were preserved during storage in the lyophilised form for at least 6 months. The data indicate good physical and chemical stability of the lyophilised preparation of TOS liposomes that can be used in clinical medicine.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/KAN200520703" target="_blank" >KAN200520703: The use of ultrasound in nanomedicine</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Pharmaceutical Sciences

ISSN

0022-3549

e-ISSN

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Volume of the periodical

99

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

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UT code for WoS article

000277132500020

EID of the result in the Scopus database

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