Frequency of Aneuploidy Related to Age in Porcine Oocytes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F11%3A%230000729" target="_blank" >RIV/00027162:_____/11:#0000729 - isvavai.cz</a>
Alternative codes found
RIV/67985904:_____/11:00365035
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Frequency of Aneuploidy Related to Age in Porcine Oocytes
Original language description
It is generally accepted that mammalian oocytes are frequently suffering from chromosome segregation errors during meiosis I. For study of this phenomenon, we have employed comparative genomic hybridization (CGH) to study the frequency of aneuploidy in porcine oocytes, including rare oocytes obtained from aged animals. In contrast to the previous reports where conventional methods, such as chromosome spreads or FISH, were used to estimate frequency of aneuploidy, our results presented here show, that the frequency of this phenomenon was overestimated in porcine oocytes. Surprisingly, despite the results from human and mouse showing an increase in the frequency of aneuploidy with advanced maternal age, our results obtained by the most accurate method currently available for scoring the aneuploidy in oocytes indicated no increase in the frequency of aneuploidy even in oocytes from aged animals.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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