The frequency of precocious segregation of sister chromatids in mouse female meiosis I is affected by genetic background

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F14%3A%230001252" target="_blank" >RIV/00027162:_____/14:#0001252 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s10577-014-9428-6" target="_blank" >http://dx.doi.org/10.1007/s10577-014-9428-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10577-014-9428-6" target="_blank" >10.1007/s10577-014-9428-6</a>

Result language
angličtina
Original language name
The frequency of precocious segregation of sister chromatids in mouse female meiosis I is affected by genetic background
Original language description
Mammalian female gametes frequently suffer from numerical chromosomal aberrations, the main cause of miscarriages and severe developmental defects. The underlying mechanisms responsible for the development of aneuploidy in oocytes are still not completely understood and remain a subject of extensive research. From studies focused on prevalence of aneuploidy in mouse oocytes, it has become obvious that reported rates of aneuploidy are strongly dependent on the method used for chromosome counting. In addition, it seems likely that differences between mouse strains could influence the frequency of aneuploidy as well; however, up till now, such a comparison has not been available. Therefore, in our study, we measured the levels of aneuploidy which has resulted from missegregation in meiosis I, in oocytes of three commonly used mouse strains-CD-1, C3H/HeJ, and C57BL/6. Our results revealed that, although the overall chromosomal numerical aberration rates were similar in all three strains, a
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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