Ingraft chimerism in lung transplantation - a study in a porcine model of obliterative bronchiolitis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F11%3A%230000762" target="_blank" >RIV/00027162:_____/11:#0000762 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Ingraft chimerism in lung transplantation - a study in a porcine model of obliterative bronchiolitis
Original language description
We studied the influence of chimerism on bronchial epithelium and obliterative bronchiolitis (OB) development in pigs. Immunosuppressed and unimmunosuppressed bronchial allografts were serially obtained after transplantation. Histology was assessed and the fluorescence in situ hybridization method for Y chromosomes using pig-specific DNA-label was used to detect recipient derived cells in graft epithelium and bronchial wall, and donor cell migration to recipient organs. Early appearance of recipient-derived cells in the airway epithelium appeared predictive of epithelial destruction and of obliteration of the bronchial lumen All allografts with preserved epithelium showed epithelial chimerism throughout the follow-up. Antirejection medication did not prevent, but delayed the appearance of Y chromosome positive cells in the epithelium, or bronchial wall.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FJ - Surgery including transplantology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Respiratory Research
ISSN
1465-9921
e-ISSN
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Volume of the periodical
12
Issue of the periodical within the volume
56
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
1-7
UT code for WoS article
000291448500001
EID of the result in the Scopus database
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