Salmonella Enteritidis with double deletion in phoP fliC-A potential live Salmonella vaccine candidate with novel characteristics for use in chickens

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F11%3A%230000783" target="_blank" >RIV/00027162:_____/11:#0000783 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.vaccine.2011.02.030" target="_blank" >http://dx.doi.org/10.1016/j.vaccine.2011.02.030</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.vaccine.2011.02.030" target="_blank" >10.1016/j.vaccine.2011.02.030</a>

Result language

angličtina

Original language name

Salmonella Enteritidis with double deletion in phoP fliC-A potential live Salmonella vaccine candidate with novel characteristics for use in chickens

Original language description

Salmonella Enteritidis mutants with deletions in phoP, fliC or phoP fliC were tested for their virulence and their ability to induce parameters of the innate and adaptive immunity in addition to their potential for serological differentiation between vaccinated, non-vaccinated and infected chickens. The double phoP fliC deletion mutant was sufficiently attenuated but not diminished in its capability to inhibit the caecal colonisation and systemic invasion of homologous Salmonella Enteritidis shortly after administration of the vaccine strain to very young chicks. Immunisation with the attenuated Delta phoP fliC mutant resulted in protective effects which were only slightly and insignificantly lower than after "immunisation" with a Salmonella wild-typestrain, indicating the capability to induce an intense adaptive immune response and protection against Salmonella exposure in older chickens. The deletion in fliC enabled the effective the differentiation between immunised and infected ch

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GJ - Diseases and animal vermin, veterinary medicine

OECD FORD branch

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Project

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Continuities

R - Projekt Ramcoveho programu EK

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Vaccine

ISSN

0264-410X

e-ISSN

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Volume of the periodical

29

Issue of the periodical within the volume

17

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

3248-3253

UT code for WoS article

000290603100024

EID of the result in the Scopus database

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