phoP, SPI1, SPI2 and aroA mutants of Salmonella Enteritidis induce a different immune response of chickens

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F15%3A%230001247" target="_blank" >RIV/00027162:_____/15:#0001247 - isvavai.cz</a>

Result on the web

<a href="http://www.veterinaryresearch.org" target="_blank" >http://www.veterinaryresearch.org</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s13567-015-0224-x" target="_blank" >10.1186/s13567-015-0224-x</a>

Result language

angličtina

Original language name

phoP, SPI1, SPI2 and aroA mutants of Salmonella Enteritidis induce a different immune response of chickens

Original language description

Poultry is the most frequent reservoir of non-typhoid Salmonella enterica for humans. Understanding the interactions between chickens and S. enterica is therefore important for vaccine design and subsequent decrease in the incidence of human salmonellosis. In this study we therefore characterized the interactions between chickens and phoP, aroA, SPI1 and SPI2 mutants of S. Enteritidis. First we tested the response of HD11 chicken macrophage-like cell line to S. Enteritidis infection monitoring the transcription of 36 genes related to immune response. All the mutants and the wild type strain induced inflammatory signaling in the HD11 cell line though the response to SPI1 mutant infection was different from the rest of the mutants. When newly hatched chickens were inoculated, the phoP as well as the SPI1 mutant did not induce an expression of any of the tested genes in the cecum. Despite this, such chickens were protected against challenge with wild-type S. Enteritidis. On the other hand

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EE - Microbiology, virology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Veterinary research

ISSN

0928-4249

e-ISSN

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Volume of the periodical

46

Issue of the periodical within the volume

96

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

1-12

UT code for WoS article

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EID of the result in the Scopus database

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