Polar Compounds Dominate in Vitro Effects of Sediment Extracts

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F11%3A%230000784" target="_blank" >RIV/00027162:_____/11:#0000784 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Polar Compounds Dominate in Vitro Effects of Sediment Extracts

Original language description

Sediment extracts from three polluted sites of the river Elbe basin,were fractionated using a novel online fractionation procedure. Resulting fractions were screened for mutagenic, aryl hydrocarbon receptor (AhR)-mediated, transthyretin (TTR)-binding, and estrogenic. activities and their potency to inhibit gap junctional intercellular communication (GJIC) to compare toxicity patterns and identify priority fractions. Additionally, more than 200 compounds and compound classes were identified using GC-MS/MS, LC-MS/MS, and HPL,C-DAD methods. For all investigated end, points, major activities were found in polar fractions, which are defined here as fractions containing dominantly compounds with atleast one polar functional group. Nonpolar PAR fractions contributed to mutagenic,andAhR-mediated activities while inhibitior of GJIC and estrogenic and TTR-binding activities were exclusively observed in the polar fractions. Known mutagens in polar fractions included nitro and dinitro-PAHs, azaare

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

DN - Environmental impact on health

OECD FORD branch

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Project

<a href="/en/project/GA525%2F08%2F1590" target="_blank" >GA525/08/1590: Identification of endocrine disrupters, genotoxins and tumor promoters in abiotic matrixes of urban and agricultural environment</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Environmental Science & Technology

ISSN

0013-936X

e-ISSN

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Volume of the periodical

45

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

2384-2390

UT code for WoS article

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EID of the result in the Scopus database

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