Identification and quantitative confirmation of dinitropyrenes and 3-nitrobenzanthrone as major mutagens in contaminated sediments

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F12%3A%230000941" target="_blank" >RIV/00027162:_____/12:#0000941 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.envint.2012.01.010" target="_blank" >http://dx.doi.org/10.1016/j.envint.2012.01.010</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.envint.2012.01.010" target="_blank" >10.1016/j.envint.2012.01.010</a>

Result language

angličtina

Original language name

Identification and quantitative confirmation of dinitropyrenes and 3-nitrobenzanthrone as major mutagens in contaminated sediments

Original language description

Polar fractions of a sediment extract of the industrial area of Bitterfeld, Germany, have been subjected for effect-directed identification of mutagens using the Ames fluctuation assay with TA98. Mutagenicity could be well recovered in several secondaryand tertiary fractions. Dinitropyrenes and 3-nitrobenzanthrone could be confirmed to contribute great shares of the observed mutagenicity. In addition, a multitude of polar polycyclic aromatic compounds has been tentatively identified in mutagenic fractions including nitro-PAHs, azaarenes, ketones, quinones, hydroxy-compounds, lactones and carboxylic acids although their contribution to mutagenicity could not be quantified due to a lack of standards. Diagnostic Salmonella strains YG1024 and YG1041 wereapplied to confirm the contribution of nitro-aromatic compounds. We suggest the inclusion of dinitropyrenes and 3-nitrobenzanthrone into sediment monitoring in order to minimize the mutagenic risk to aquatic organisms and to human health.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

DN - Environmental impact on health

OECD FORD branch

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Project

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Continuities

R - Projekt Ramcoveho programu EK

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Environment International

ISSN

0160-4120

e-ISSN

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Volume of the periodical

44

Issue of the periodical within the volume

SEP 1 2012

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

31-39

UT code for WoS article

000304745900005

EID of the result in the Scopus database

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