Benzo[a]pyrene and tumor necrosis factor-alpha coordinately increase genotoxic damage and the production of proinflammatory mediators in alveolar epithelial type II cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F11%3A%230000813" target="_blank" >RIV/00027162:_____/11:#0000813 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/11:00366512 RIV/68378041:_____/11:00366512

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Benzo[a]pyrene and tumor necrosis factor-alpha coordinately increase genotoxic damage and the production of proinflammatory mediators in alveolar epithelial type II cells

Original language description

Alveolar type II epithelial (AEII) cells regulate lung inflammatory response and, simultaneously, they are a target of environmental carcinogenic factors. We employed an in vitro model of rat AEII cells, the RLE-6TN cell line, in order to analyze the interactive effects of tumor necrosis factor-alpha (TNF-alpha), a cytokine which plays a key role in the initiation of inflammatory responses in the lung, and benzo[a]pyrene (BaP), a highly carcinogenic polycyclic aromatic hydrocarbon. TNF-alpha strongly augmented the formation of stable BaP diol epoxide-DNA adducts in AEII cells, which was associated with enhanced p53-Ser15 phosphorylation and decreased cell survival. The increased genotoxicity of BaP was associated with altered expression of cytochrome P450 (CYP) enzymes involved in its bioactivation, a simultaneous suppression of CYP1A1 and enhancement of CYP1B1 expression. Importantly, BaP and TNE-alpha acted synergistically to upregulate key inflammatory regulators in AEII cells, incl

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

DN - Environmental impact on health

OECD FORD branch

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Project

<a href="/en/project/GAP503%2F11%2F1227" target="_blank" >GAP503/11/1227: Interactions of inflammatory mediators and Ah receptor signaling in toxic effects of polycyclic aromatic hydrocarbons</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Toxicology Letters

ISSN

0378-4274

e-ISSN

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Volume of the periodical

206

Issue of the periodical within the volume

2

Country of publishing house

IE - IRELAND

Number of pages

9

Pages from-to

121-129

UT code for WoS article

000295298800002

EID of the result in the Scopus database

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