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Genotoxicity of 7H-dibenzo[c,g]carbazole and Its Tissue-Specific Derivatives in Human Hepatoma HepG2 Cells Is Related to CYP1A1/1A2 Expression

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F11%3A%230000816" target="_blank" >RIV/00027162:_____/11:#0000816 - isvavai.cz</a>

  • Alternative codes found

    RIV/68378041:_____/11:00368653

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Genotoxicity of 7H-dibenzo[c,g]carbazole and Its Tissue-Specific Derivatives in Human Hepatoma HepG2 Cells Is Related to CYP1A1/1A2 Expression

  • Original language description

    The goal of this study was to investigate the genotoxicity of 7H-dibenzo[c,g]carbazole (DBC), a ubiquitous environmental pollutant, and its methyl derivatives, 5,9-dimethylDBC (DiMeDBC), a strict hepatocarcinogen, and N-methylDBC (N-MeDBC), a specific sarcomagen in human hepatoma HepG2 cells, and to infer potential mechanisms underlying the biological activity of particular carcinogen. All dibenzocarbazoles, regardless the tissue specificity, induced significant DNA strand break levels and micronuclei in HepG2 cells; though a mitotic spindle dysfunction rather than a chromosome breakage was implicated in N-MeDBC-mediated micronucleus formation. While DBC and N-MeDBC produced stable DNA adducts followed with p53 protein phosphorylation at Ser-15, DiMeDBC failed. A significant increase in DNA strand breaks following incubation of exposed cells with a repair-specific endonuclease (Fpg protein) suggested that either oxidative DNA damage or unstable DNA-adducts might underlie DiMeDBC genoto

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    DN - Environmental impact on health

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/2B08005" target="_blank" >2B08005: New approaches to study the toxicity of the air pollution and their contribution to assess limits for selected pollutants.</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Environmental and Molecular Mutagenesis

  • ISSN

    0893-6692

  • e-ISSN

  • Volume of the periodical

    52

  • Issue of the periodical within the volume

    8

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    10

  • Pages from-to

    636-645

  • UT code for WoS article

    000296861100005

  • EID of the result in the Scopus database