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DNA adduct formation by 7H-dibenzo[c,g]carbazole and its tissue- and organ-specific derivatives in Chinese hamster V79 cell lines stably expressing cytochrome P450 enzymes

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F04%3A00107494" target="_blank" >RIV/68378041:_____/04:00107494 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    DNA adduct formation by 7H-dibenzo[c,g]carbazole and its tissue- and organ-specific derivatives in Chinese hamster V79 cell lines stably expressing cytochrome P450 enzymes

  • Original language description

    In this study the relations between the tissue specificity and 32P-postlabeled adduct patterns produced by 7H-dibenzo[c,g]carbazole (DBC), N-methyldibenzo[c,g]carbazole (MeDBC) and 5,9-dimethyldibenzo[c,g]carbazole (diMeDBC) using a panel of Chinese hamster V79 cell lines stably expressing human CYP1A1 and CYP1A2 and /or N-acetyltransferase. The similarities between the DNA adduct pattern produced by DBC and MeDBC in V79MZh1A1 and V79MZh1A2 cells suggest that biotransformation mediated via CYP1A1 and CYP1A2 might depend on a PAH-type pathway involving the aromatic ring system

  • Czech name

    Tvorba DNA aduktů 7H-dibenzo[c,g]karbazolem a jejich tkáňové a orgán-specifické deriváty ve V79 buněčných liniích Čínského křečka stabilně exprimujících enzymy cytochromu P450

  • Czech description

    Byl studován vztah mezi tkáňovou specifitou a 32P-značenými DNA adukty indukovanými 7H-dibenzo[c,g]karbazolem (DBC), N-metyldibenzo[c,g]karbazolem (MeDBC) a 5,9-dimetyldibenzo[c,g]karbazolem (diMeDBC) za použití sady V79 buněčných linií Čínského křečka stabilně exprimujících lidské CYP1A1 a CYP1A2 a/nebo N-acetyltransferázu. Analogie charakteristik DNA aduktů indukovaných DBC a MeDBC v buňkách V79MZh1A1 a V79MZhA2 může záviset na typu vazby PAU v systému aromatických jader

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    DN - Environmental impact on health

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2004

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Environmental and Molecular Mutagenesis

  • ISSN

    0893-6692

  • e-ISSN

  • Volume of the periodical

    44

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    11

  • Pages from-to

    448-458

  • UT code for WoS article

  • EID of the result in the Scopus database