Gamma delta T lymphocytes are recruited into the inflamed uterus of bitches suffering from pyometra

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F12%3A%230000922" target="_blank" >RIV/00027162:_____/12:#0000922 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.tvjl.2012.05.024" target="_blank" >http://dx.doi.org/10.1016/j.tvjl.2012.05.024</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.tvjl.2012.05.024" target="_blank" >10.1016/j.tvjl.2012.05.024</a>

Result language

angličtina

Original language name

Gamma delta T lymphocytes are recruited into the inflamed uterus of bitches suffering from pyometra

Original language description

Very little is known about the occurrence of immune system cells in the canine uterus. The aim of this study was to generate information about lymphocyte subsets that are present in the healthy canine uterus and that are recruited under inflammatory conditions caused by pyometra. Using immunohistochemistry and flow cytometry, a significant influx of ?? T lymphocytes was found in pyometra samples mainly due to recruitment of ??(+)/CD8(-) T lymphocytes. The relative expression of genes encoding selected cytokines/chemokines was evaluated in samples from healthy and pyometra-affected uteri. Expression of pro-inflammatory cytokines (including IL-1ß, TNF-?, IL-8, IL-17 and IFN-?) and chemokines (including CXCL10, CCL4 and CCL5) was upregulated in pyometra samples confirming the presence of inflammation. In contrast, the expression of the homeostatic chemokine CCL25 and of the anti-inflammatory cytokine IL-10 was downregulated and unchanged, respectively. Copyright c 2012 Elsevier Ltd. All r

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GJ - Diseases and animal vermin, veterinary medicine

OECD FORD branch

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Project

<a href="/en/project/ED0006%2F01%2F01" target="_blank" >ED0006/01/01: Center for Advanced Microbiology & Immunology Research in Veterinary Medicine</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Veterinary Journal

ISSN

1090-0233

e-ISSN

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Volume of the periodical

194

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

303-308

UT code for WoS article

000313224300012

EID of the result in the Scopus database

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