The local immune response of mice after Helicobacter suis infection: strain differences and distinction with Helicobacter pylori

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F12%3A%230000932" target="_blank" >RIV/00027162:_____/12:#0000932 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1186/1297-9716-43-75" target="_blank" >http://dx.doi.org/10.1186/1297-9716-43-75</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/1297-9716-43-75" target="_blank" >10.1186/1297-9716-43-75</a>

Result language

angličtina

Original language name

The local immune response of mice after Helicobacter suis infection: strain differences and distinction with Helicobacter pylori

Original language description

Helicobacter (H.) suis colonizes the stomach of pigs and is the most prevalent gastric non-H. pylori Helicobacter species in humans. Limited information is available on host immune responses after infection with this agent and it is unknown if variationin virulence exists between different H. suis strains. Therefore, BALB/c and C57BL/6 mice were used to compare colonization ability and gene expression of various inflammatory cytokines, as determined by real-time PCR, after experimental infection with 9different H. suis strains. All strains were able to persist in the stomach of mice, but the number of colonizing bacteria at 59 days post inoculation was higher in stomachs of C57BL/6 mice compared to BALB/c mice. All H. suis strains caused an upregulation of interleukin (IL)-17, which was more pronounced in BALB/c mice. This upregulation was inversely correlated with the number of colonizing bacteria. Most strains also caused an upregulation of regulatory IL-10, positively correlating

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GJ - Diseases and animal vermin, veterinary medicine

OECD FORD branch

—

Project

<a href="/en/project/ED0006%2F01%2F01" target="_blank" >ED0006/01/01: Center for Advanced Microbiology & Immunology Research in Veterinary Medicine</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Veterinary Research

ISSN

0928-4249

e-ISSN

—

Volume of the periodical

43

Issue of the periodical within the volume

75

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

—

UT code for WoS article

000313160000001

EID of the result in the Scopus database

—