Evidence for a primate origin of zoonotic Helicobacter suis colonizing domesticated pigs
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F18%3A43876411" target="_blank" >RIV/62157124:16270/18:43876411 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1038/ismej.2017.145" target="_blank" >https://doi.org/10.1038/ismej.2017.145</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/ismej.2017.145" target="_blank" >10.1038/ismej.2017.145</a>
Alternative languages
Result language
angličtina
Original language name
Evidence for a primate origin of zoonotic Helicobacter suis colonizing domesticated pigs
Original language description
Helicobacter suis is the second most prevalent Helicobacter species in the stomach of humans suffering from gastric disease. This bacterium mainly inhabits the stomach of domesticated pigs, in which it causes gastric disease, but it appears to be absent in wild boars. Interestingly, it also colonizes the stomach of asymptomatic rhesus and cynomolgus monkeys. The origin of modern human-, pig- or non-human primate-associated H. suis strains in these respective host populations was hitherto unknown. Here we show that H. suis in pigs possibly originates from non-human primates. Our data suggest that a host jump from macaques to pigs happened between 100 000 and 15 000 years ago and that pig domestication has had a significant impact on the spread of H. suis in the pig population, from where this pathogen occasionally infects humans. Thus, in contrast to our expectations, H. suis appears to have evolved in its main host in a completely different way than its close relative Helicobacter pylori in humans.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ISME Journal
ISSN
1751-7362
e-ISSN
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Volume of the periodical
12
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
77-86
UT code for WoS article
000418293300006
EID of the result in the Scopus database
2-s2.0-85038608831