Ovarian disorders in immature rats after postnatal exposure to environmental polycyclic aromatic hydrocarbons
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F13%3A%230000960" target="_blank" >RIV/00027162:_____/13:#0000960 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/jat.1714" target="_blank" >http://dx.doi.org/10.1002/jat.1714</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jat.1714" target="_blank" >10.1002/jat.1714</a>
Alternative languages
Result language
angličtina
Original language name
Ovarian disorders in immature rats after postnatal exposure to environmental polycyclic aromatic hydrocarbons
Original language description
The study investigated the effects of postnatal exposure to polycyclic aromatic hydrocarbons (PAHs) on the development of the rat ovary. Neonates were injected on each postnatal day 1-14 with benzo(a) pyrene (BaP), benz(a) anthracene (BaA) and benzo(k) fluoranthene (BkF) (0.1, 1.0, 5.0 or 10.0mg kg(-1)), ethynylestradiol (EE; 1.0 mu g kg(-1)) or a vehicle (control group). The rats were killed on day 23. Postnatal exposure to BaP increased the total number of antral follicles in ovaries and the number ofnonatretic follicles as a result of a lower degree of apoptosis of granulosa cells, and the thickness of theca cell layers. Similar histological findings were observed after BaA administration. Conversely, BkF exposure caused a decrease in the number ofantral follicles, but did not alter the other investigated parameters. Degeneration of primordial oocytes after exposure to PAHs was observed only after exposure to BaP. Treatment with BaP at doses of 1.0 and 10.0 mg kg(-1) impaired 28.1
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
DN - Environmental impact on health
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED0006%2F01%2F01" target="_blank" >ED0006/01/01: Center for Advanced Microbiology & Immunology Research in Veterinary Medicine</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JOURNAL OF APPLIED TOXICOLOGY
ISSN
0260-437X
e-ISSN
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Volume of the periodical
33
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
90-99
UT code for WoS article
000314069700002
EID of the result in the Scopus database
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