Morphological and functional disorders of the immature rat uterus after postnatal exposure to benz(a)anthracene and benzo(k)fluoranthene

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F09%3A%230000486" target="_blank" >RIV/00027162:_____/09:#0000486 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Morphological and functional disorders of the immature rat uterus after postnatal exposure to benz(a)anthracene and benzo(k)fluoranthene

Original language description

The objective of this study was to investigate the effects of postnatal exposure to benz(a)anthracene (B(a)A) and benzo(k)fluoranthene (B(k)F) on the development of the rat uterus. Neonates were injected subcutaneously on each postnatal day 1-14 with B(a)A (0.1, 1.0 or 10.0 mg/kg), B(k)F (0.1, 1.0 or 5.0 mg/kg), ethynylestradiol (EE; 1.0 ug/kg) or a vehicle. The rats were killed on day 23. All doses of B(a)A and B(k)F induced a significant reduction of the uterine weight, a reduction of the estrogen receptor alpha expression in the luminal epithelium, glandular epithelium and stromal cells. Moreover, the uterotrophic response to EE (three-day administration of 1.0 ug/kg on postnatal days 20-22) in rats exposed to B(a)A, B(k)F and EE was significantly lower than in controls. The study showed that postnatal exposure to B(a)A or B(k)F results in morphological and functional disorders of the immature rat uterus.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GJ - Diseases and animal vermin, veterinary medicine

OECD FORD branch

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Project

<a href="/en/project/GA525%2F05%2F2695" target="_blank" >GA525/05/2695: Effects of neonatal exposure to polycyclic aromatic hydrocarbons on the reproductive and immune systém</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Environmental Toxicology and Pharmacology

ISSN

1382-6689

e-ISSN

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Volume of the periodical

27

Issue of the periodical within the volume

3

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

6

Pages from-to

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UT code for WoS article

000264387200014

EID of the result in the Scopus database

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