The Role of the qacA Gene in Mediating Resistance to Quaternary Ammonium Compounds
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F13%3A%230000970" target="_blank" >RIV/00027162:_____/13:#0000970 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1089/mdr.2012.0154" target="_blank" >http://dx.doi.org/10.1089/mdr.2012.0154</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1089/mdr.2012.0154" target="_blank" >10.1089/mdr.2012.0154</a>
Alternative languages
Result language
angličtina
Original language name
The Role of the qacA Gene in Mediating Resistance to Quaternary Ammonium Compounds
Original language description
Conditions facilitating resistance to quaternary ammonium compounds (QACs) were investigated in Staphylococcus aureus SK982 exposed to benzalkonium chloride (BAC; a member of QACs) under various circumstances. S. aureus SK982 carrying the qacA gene encoding for resistance to QACs was grown in the presence of stable or gradually increasing concentrations of BAC, or it was exposed to this antiseptic in the exponential phase of growth. Bacteria cultivated in the highest BAC concentrations that did not retard their growth comparing to the untreated control were subjected to real-time quantitative polymerase chain reaction analysis for relative expression of the efflux genes qacA and norA. Under such conditions, S. aureus SK982 tolerated a relatively low stable concentration of BAC (1.22 mg/L) when compared with a gradually increasing antiseptic concentration (tolerance of 4.88mg/L). However, in both cases, qacA expression was not significant. The culture exposed in the exponential phase of
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
MICROBIAL DRUG RESISTANCE
ISSN
1076-6294
e-ISSN
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Volume of the periodical
19
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
160-167
UT code for WoS article
000319399900002
EID of the result in the Scopus database
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