Distribution of porcine monocytes in different lymphoid tissues and the lungs during experimental Actinobacillus pleuropneumoniae infection and the role of chemokines

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F13%3A%230001014" target="_blank" >RIV/00027162:_____/13:#0001014 - isvavai.cz</a>
Result on the web
<a href="http://www.veterinaryresearch.org/content/44/1/98" target="_blank" >http://www.veterinaryresearch.org/content/44/1/98</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/1297-9716-44-98" target="_blank" >10.1186/1297-9716-44-98</a>

Result language
angličtina
Original language name
Distribution of porcine monocytes in different lymphoid tissues and the lungs during experimental Actinobacillus pleuropneumoniae infection and the role of chemokines
Original language description
Monocytes play an essential role in the defense against bacterial pathogens. Bone marrow ( BM) and peripheral blood ( PB) monocytes in pigs consist of the main "steady-state" subpopulations: CD14(hi)/CD163(-)/SLA-DR- and CD14(low)/CD163(+)/SLA-DR+. During inflammation, the subpopulation of "inflammatory" monocytes expressing very high levels of CD163, but lacking the SLA-DR molecule (being CD14(low)/CD163(+)/SLA-DR-) appears in the BM and PB and replaces the CD14(low)/CD163(+)/SLA-DR+ subpopulation. However, current knowledge of monocyte migration into inflamed tissues in pigs is limited. The aim of the present study was to evaluate the distribution of "inflammatory" CD14(low)/CD163(+)/SLA-DR- monocytes during experimental inflammation induced by Actinobacillus pleuropneumoniae (APP) and a possible role for chemokines in attracting "inflammatory" CD14(low)/CD163(+)/SLA-DR- monocytes into the tissues. Monocyte subpopulations were detected by flow cytometry. Chemokines and chemokine rece
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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