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Inhibition of vacuolar ATPase attenuates the TRAIL-induced activation of caspase-8 and modulates the trafficking of TRAIL receptosomes

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F13%3A%230001062" target="_blank" >RIV/00027162:_____/13:#0001062 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1111/febs.12347" target="_blank" >http://dx.doi.org/10.1111/febs.12347</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/febs.12347" target="_blank" >10.1111/febs.12347</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Inhibition of vacuolar ATPase attenuates the TRAIL-induced activation of caspase-8 and modulates the trafficking of TRAIL receptosomes

  • Original language description

    Tumour necrosis factor (TNF) related apoptosis inducing ligand (TRAIL), a membrane-bound ligand from the TNF family, has attracted significant attention due to its rather specific and effective ability to induce apoptotic death in various types of cancercells via binding to and activating its pro-apoptotic death receptors. However, a significant number of primary cancer cells often develop resistance to TRAIL treatment, and the signalling platform behind this phenomenon is not fully understood. Upon blocking endosomal acidification by the vacuolar ATPase (V-ATPase) inhibitors bafilomycin A1 (BafA1) or concanamycin A, we observed a significantly reduced initial sensitivity of several, mainly colorectal, tumour cell lines to TRAIL-induced apoptosis. Incells pretreated with these inhibitors, the TRAIL-induced processing of caspase-8 and the aggregation and trafficking of the TRAIL receptor complexes were temporarily attenuated. Nuclear factor B or mitogen activated protein/stress kinase

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GAP301%2F11%2F1730" target="_blank" >GAP301/11/1730: Changes of lipid metabolism and composition during colorectal carcinogenesis - the effects of butyrate and polyunsaturated fatty acids</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    FEBS JOURNAL

  • ISSN

    1742-4658

  • e-ISSN

  • Volume of the periodical

    280

  • Issue of the periodical within the volume

    14

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    15

  • Pages from-to

    3436-3450

  • UT code for WoS article

    000327128700023

  • EID of the result in the Scopus database