Total globozoospermia associated with increased frequency of immature spermatozoa with chromatin defects and aneuploidy: a case report
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F14%3A%230001107" target="_blank" >RIV/00027162:_____/14:#0001107 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/and.12156" target="_blank" >http://dx.doi.org/10.1111/and.12156</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/and.12156" target="_blank" >10.1111/and.12156</a>
Alternative languages
Result language
angličtina
Original language name
Total globozoospermia associated with increased frequency of immature spermatozoa with chromatin defects and aneuploidy: a case report
Original language description
Globozoospermia, characterised by the presence of round spermatozoa lacking acrosomes in an ejaculate, is a known cause of male infertility. Semen analysis, including sperm chromatin structure assay, toluidine blue, chromomycin A3 and aniline blue staining and fluorescence in situ hybridisation, was performed in an infertile globozoospermic patient to establish to which extent these genetic factors contributed to his infertility. No spermatozoa capable of hyaluronan (HA) binding were detected in the HAbinding assay. Increased rates of immature spermatozoa with defective replacement of histones by protamines, DNA breaks and disturbed chromatin integrity and sperm aneuploid for the sex chromosomes were observed. Intracytoplasmic sperm injection (ICSI) was used in three in vitro fertilisation (IVF) cycles, and enough morphologically well-developing embryos were obtained in each cycle. However, no pregnancy was achieved. The infertility of our couple, resistant to IVF/ICSI treatment, was
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Andrologia
ISSN
0303-4569
e-ISSN
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Volume of the periodical
46
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
831-836
UT code for WoS article
000342811000003
EID of the result in the Scopus database
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