In Vitro and in Silico Derived Relative Effect Potencies of Ah-Receptor-Mediated Effects by PCDD/Fs and PCBs in Rat, Mouse, and Guinea Pig CALUX Cell Lines
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F14%3A%230001175" target="_blank" >RIV/00027162:_____/14:#0001175 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1021/tx5001255" target="_blank" >http://dx.doi.org/10.1021/tx5001255</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/tx5001255" target="_blank" >10.1021/tx5001255</a>
Alternative languages
Result language
angličtina
Original language name
In Vitro and in Silico Derived Relative Effect Potencies of Ah-Receptor-Mediated Effects by PCDD/Fs and PCBs in Rat, Mouse, and Guinea Pig CALUX Cell Lines
Original language description
Species-specific relative effect potencies (REPs), responses of dioxin-like compounds (DLCs), were assessed using chemical-activated luciferase gene expression assays derived from guinea pig, rat, and mouse cell lines. Almost all 20 congeners tested in the rodent cell lines were partial agonists and less efficacious than 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). REPs were calculated for each congener using concentrations at which 20% of the maximal TCDD response was reached; the REP values obtained for PCDD/Fs were comparable with their toxic equivalency factors assigned by the World Health Organization (WHO-TEF), while those for PCBs were in general lower than the WHO-TEF values. The guinea pig cell line was the most sensitive as indicated by the 20% effect concentrations of TCDD of 1.5, 5.6, and 11.0 pM for guinea pig, rat, and mouse cells, respectively. In order to provide REP values for all WHO-TEF assigned compounds, quantitative structure activity relationship (QSAR) models wer
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chemical Research in Toxicology
ISSN
0893-228X
e-ISSN
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Volume of the periodical
27
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
1120-1132
UT code for WoS article
000339462700005
EID of the result in the Scopus database
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