Revised relative potency values for PCDDs, PCDFs, and non-ortho-substituted PCBs for the optimized H4IIE-luc in vitro bioassay
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F13%3A00071147" target="_blank" >RIV/00216224:14310/13:00071147 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s11356-013-1770-2" target="_blank" >http://dx.doi.org/10.1007/s11356-013-1770-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11356-013-1770-2" target="_blank" >10.1007/s11356-013-1770-2</a>
Alternative languages
Result language
angličtina
Original language name
Revised relative potency values for PCDDs, PCDFs, and non-ortho-substituted PCBs for the optimized H4IIE-luc in vitro bioassay
Original language description
While the World Health Organization 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) equivalency factors are useful estimates of relative potencies of mixtures when conducting risk assessments, they are not useful when comparing the results of bioassays such as the H4IIE-luc to concentrations of TCDD equivalents calculated from instrumental analyses. Since there are thousands of dioxin-like compounds (DLCs), one use of screening assays is to determine if all of the aryl hydrocarbon receptor (AhR) active DLCsin a mixture have been accounted for in instrumental analyses. For this purpose, bioassay-specific relative potency (ReP) values are needed. RePs of 21 polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls that exhibit effects mediated through the AhR were determined by use of the H4IIE-luc assay. Different values of RePs are derived, depending on the statistical, curve-fitting methods used to derive them from the dose-response relati
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
DN - Environmental impact on health
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED0001%2F01%2F01" target="_blank" >ED0001/01/01: CETOCOEN</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Environmental Science and Pollution Research
ISSN
0944-1344
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
12
Country of publishing house
DE - GERMANY
Number of pages
10
Pages from-to
8590-8599
UT code for WoS article
000327498600029
EID of the result in the Scopus database
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