A deep phylogeny of viral and cellular right-hand polymerases

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F15%3A%230001319" target="_blank" >RIV/00027162:_____/15:#0001319 - isvavai.cz</a>
Result on the web
<a href="http://www.journals.elsevier.com/infection-genetics-and-evolution" target="_blank" >http://www.journals.elsevier.com/infection-genetics-and-evolution</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.meegid.2015.09.026" target="_blank" >10.1016/j.meegid.2015.09.026</a>

Result language
angličtina
Original language name
A deep phylogeny of viral and cellular right-hand polymerases
Original language description
Right-hand polymerases are important players in genome replication and repair in cellular organisms as well as in viruses. Although the evolutionary relationships of right-hand polymerases within each family have been proposed, evolutionary relationshipsbetween families remain elusive because their sequence similarity is too low to allow classical phylogenetic analyses. The structure of viral RNA-dependent RNA polymerases recently was shown to be useful in inferring their evolution. Here, we address evolutionary relationships between right-hand polymerase families by combining sequence and structure information. We used a set of 22 viral and cellular polymerases representing all right-hand polymerase families with known protein structure. In contrastto previous studies, which focused only on the evolution of particular families, the current approach allowed us to present the first robust phylogenetic analysis unifying evolution of all right-hand polymerase families. All polymerase fa
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Project
<a href="/en/project/LO1218" target="_blank" >LO1218: Healthy animal as a source of wholesome food</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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