Evolution of Tertiary Structure of Viral RNA Dependent Polymerases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F14%3A00429370" target="_blank" >RIV/60077344:_____/14:00429370 - isvavai.cz</a>

Alternative codes found

RIV/00027162:_____/14:#0001147 RIV/60460709:41340/14:65006 RIV/60076658:12310/14:43887336

Result on the web

<a href="http://dx.doi.org/10.1371/journal.pone.0096070" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0096070</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0096070" target="_blank" >10.1371/journal.pone.0096070</a>

Result language

angličtina

Original language name

Evolution of Tertiary Structure of Viral RNA Dependent Polymerases

Original language description

Viral RNA dependent polymerases (vRdPs) are present in all RNA viruses; unfortunately, their sequence similarity is too low for phylogenetic studies. Nevertheless, vRdP protein structures are remarkably conserved. In this study, we used the structural similarity of vRdPs to reconstruct their evolutionary history. The major strength of this work is in unifying sequence and structural data into a single quantitative phylogenetic analysis, using powerful a Bayesian approach. The resulting phylogram of vRdPs demonstrates that RNA-dependent DNA polymerases (RdDPs) of viruses within Retroviridae family cluster in a clearly separated group of vRdPs, while RNA-dependent RNA polymerases (RdRPs) of dsRNA and +ssRNA viruses are mixed together. This evidence supports the hypothesis that RdRPs replicating +ssRNA viruses evolved multiple times from RdRPs replicating +dsRNA viruses, and vice versa. Moreover, our phylogram may be presented as a scheme for RNA virus evolution. The results are in concor

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLoS ONE

ISSN

1932-6203

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

14

Pages from-to

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UT code for WoS article

000336838000021

EID of the result in the Scopus database

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