Differences in host breed and diet influence colonization by Campylobacter jejuni and induction of local immune responses in chicken
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F16%3AN0000027" target="_blank" >RIV/00027162:_____/16:N0000027 - isvavai.cz</a>
Result on the web
<a href="https://gutpathogens.biomedcentral.com/articles/10.1186/s13099-016-0133-1" target="_blank" >https://gutpathogens.biomedcentral.com/articles/10.1186/s13099-016-0133-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s13099-016-0133-1" target="_blank" >10.1186/s13099-016-0133-1</a>
Alternative languages
Result language
angličtina
Original language name
Differences in host breed and diet influence colonization by Campylobacter jejuni and induction of local immune responses in chicken
Original language description
Chickens are regarded as the main reservoir for human campylobacteriosis. Little is known about the interaction between Campylobacter jejuni (C. jejuni) and chickens. This interaction may be influenced by the stage of maturation of the immune system, developing gut microbiota composition and other factors including breed and diet. Our aim was to investigate the impact of breed, and diet on C. jejuni colonization and host immune responses in chickens. Birds were inoculated with 104 colony forming units (CFU) of C. jejuni or diluent at one (Exp. 1) or 22 (Exp. 2) days post hatch. We compared local immune cell subpopulations, cytokine expression levels, and gut microbiota composition between broiler-type (BT) and layer-type (LT) birds fed with either commercial broiler feed (bf ) or layer feed (lf ). Lower colonization rates were observed in the older age group independent of breed and diet. Independent of breed, birds fed with bf showed higher CFU of C. jejuni compared to lf-fed groups. Campylobacter jejuni-inoculation had a significant effect on lymphocyte numbers and cytokine expression levels in BT birds independent of feeding strategy (p < 0.05). These effects were not detected in LT birds, only LT birds fed with bf showed a significant increase in IL-8-expression at 7 days post C. jejuni inoculation compared to LT-control birds (p < 0.05). Diet influenced gut microbiota composition in a comparable manner between BT and LT birds, but changes in microbiota composition associated with C. jejuni inoculation varied between breeds. Diet and breed influenced C. jejuni colonization, immune responses and microbiota composition to a different extent comparing between LT and BT birds. The mechanisms behind these differences have to be elucidated further. Our results suggest that selection for more resistant breeds in combination with adapted feeding strategies may help to reduce Campylobacter colonization levels in commercial poultry in the future.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
GJ - Diseases and animal vermin, veterinary medicine
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED0006%2F01%2F01" target="_blank" >ED0006/01/01: Center for Advanced Microbiology & Immunology Research in Veterinary Medicine</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Gut Pathogens
ISSN
1757-4749
e-ISSN
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Volume of the periodical
Neuveden
Issue of the periodical within the volume
8
Country of publishing house
GB - UNITED KINGDOM
Number of pages
14
Pages from-to
nestrankovano
UT code for WoS article
000387823500001
EID of the result in the Scopus database
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