Effect of dietary fish oil on expression of liver genes controlling cholesterol homeostasis: comparison of two animal models

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F16%3AN0000147" target="_blank" >RIV/00027162:_____/16:N0000147 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43210/16:43910214
Result on the web
<a href="https://mnet.mendelu.cz/mendelnet2016/mnet_2016_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2016/mnet_2016_full.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Effect of dietary fish oil on expression of liver genes controlling cholesterol homeostasis: comparison of two animal models
Original language description
The aim of this study was to compare the effect of the fish oil, respectively its main component, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the expression of genes PPAR alpha, SREBP-2, Insig-1, Hmgcr and Ldlr which control cholesterol homeostasis in the liver of rats (Wistar Albino; n = 32) and pigs (Large White x Landrace; n = 32). Rats and pigs were randomly assigned into two groups of 16 animals and fed ten weeks by the diet with either 2.5% of fish oil (group F; source of eicosapentaenoic and docosahexaenoic acid, EPA+DHA) or 2.5% of palm oil (group P; high content of saturated fatty acids; control group). Dietary fish oil relative to palm oil increased PPAR alpha and SREBP-2 gene expression much strongly (P<0.01) in the pig liver in comparison with the rat liver, but expression of Insig-1 and Hmgcr genes in the liver of the F-pigs relative to the expression of these genes in the liver of the P-pigs was substantially lower (P<0.01 and P<0.05, respectively) as compared to rats.
Czech name
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Czech description
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Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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