Effect of T-2 toxin-contaminated diet on common carp (Cyprinus carpio L.)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F17%3AN0000113" target="_blank" >RIV/00027162:_____/17:N0000113 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14310/17:00095917 RIV/62156489:43210/17:43909859

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S1050464816307276" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1050464816307276</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.fsi.2016.11.032" target="_blank" >10.1016/j.fsi.2016.11.032</a>

Result language

angličtina

Original language name

Effect of T-2 toxin-contaminated diet on common carp (Cyprinus carpio L.)

Original language description

The T-2 toxin, a fungal metabolite produced by Fusarium molds, occurs in a range of agriculture products. Reduced availability of fish meal has led to increasing use of cereals as a source of protein in commercial aquaculture feeds, which has increased the potential for mycotoxin contamination. The purpose of this study was to investigate toxicity of T-2 toxin intake in common carp (Cyprinus carpio L.) using haematological, biochemical and immunological parameters and oxidative stress indices. In a four-week feeding trial, fish were fed a commercial diet with 5.3 mg/kg T-2 toxin added. Ingestion of contaminated diet did not lead to mortality of fish, probably due to lower feed intake. On the other hand, it significantly affected haematological variables such as haematocrit, haemoglobin, red blood cell counts leading to anemia and white blood cell counts leading to leukopenia due to lymphopenia. Plasma glucose concentration and alanine amino transferase activity showed a significant increase while triglycerides concentration decreased. Activity of ceruloplasmin was significantly decreased in plasma. Further, liver glutathione S-transferase activity was significantly increased and catalase activity decreased, in parallel with a significant increase in caudal kidney catalase activity and a decrease in glutathione peroxidase activity. Finally, lipid peroxidation (detected as malondialdehyde) was significantly increased in the liver and caudal kidney. Changes in non-specific immune response and cytokine levels in head kidney indicated immune system sensitivity to T-2 toxin. Overall, the results demonstrate that this feed-borne mycotoxin is able to induce anaemia and oxidative stress and cause changes in the immune response of common carp.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

40301 - Veterinary science

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

FISH & SHELLFISH IMMUNOLOGY

ISSN

1050-4648

e-ISSN

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Volume of the periodical

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Issue of the periodical within the volume

60

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

458-465

UT code for WoS article

000392770000050

EID of the result in the Scopus database

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