Elevated concentrations of T-2 toxin cause oxidative stress in the rainbow trout (Oncorhynchus mykiss)

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F18%3A43911739" target="_blank" >RIV/62156489:43210/18:43911739 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16170/18:43876934 RIV/62157124:16270/18:43876934 RIV/62157124:16370/18:43876934
Result on the web
<a href="https://doi.org/10.1111/anu.12613" target="_blank" >https://doi.org/10.1111/anu.12613</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/anu.12613" target="_blank" >10.1111/anu.12613</a>

Result language
angličtina
Original language name
Elevated concentrations of T-2 toxin cause oxidative stress in the rainbow trout (Oncorhynchus mykiss)
Original language description
T-2 toxin is a mycotoxin produced by several Fusarium fungi that can contaminate plant components used in feed for aquaculture. The aim of this 28-day study was to investigate the effect of the T-2 toxin in feed in concentrations 1.0 and 1.8 mg/kg (0.01 mg/kg b.w. and 0.018 mg/kg b.w.) on the oxidative stress markers and on the detoxifying enzymes of the rainbow trout. The results showed that T-2 toxin in both tested concentrations induced oxidative stress and antioxidant defence in the liver of trout manifesting by the increase in activities of enzymes glutathione-S-transferase, glutathione reductase and glutathione peroxidase and the decrease in the catalase activity. The increase in lipid peroxidation was recorded only in the higher concentration of T-2 toxin. Ceruloplasmin activity in the plasma increased at both tested concentrations, and the ferric reducing ability of the plasma increased at the higher toxin concentration. The T-2 toxin in feed caused alteration of the total protein, albumin and triacylglycerols as well as the alkaline phosphatase activity in the plasma. Despite no changes in histological examination were found, the influence of T-2 toxin on scavenger system may result in increased sensitivity to other stress factors.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
40103 - Fishery

Project
<a href="/en/project/QJ1210013" target="_blank" >QJ1210013: Technology of the freshwater fish breeding with using of re-circulatory systems of Danish type focused on the methods of effective treatment of environment and veterinary care</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)