Functional evolution of subolesin/Akirin
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F18%3AN0000060" target="_blank" >RIV/00027162:_____/18:N0000060 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/18:00497446 RIV/60076658:12310/18:43897695
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fphys.2018.01612/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fphys.2018.01612/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fphys.2018.01612" target="_blank" >10.3389/fphys.2018.01612</a>
Alternative languages
Result language
angličtina
Original language name
Functional evolution of subolesin/Akirin
Original language description
The Subolesin/Akirin constitutes a good model for the study of functional evolution because these proteins have been conserved throughout the metazoan and play a role in the regulation of different biological processes. Here, we investigated the evolutionary history of Subolesin/Akirin with recent results on their structure, protein-protein interactions and function in different species to provide insights into the functional evolution of these regulatory proteins, and their potential as vaccine antigens for the control of ectoparasite infestations and pathogen infection. The results suggest that Subolesin/Akirin evolved conserving not only its sequence and structure, but also its function and role in cell interactome and regulome in response to pathogen infection and other biological processes. This functional conservation provides a platform for further characterization of the function of these regulatory proteins, and how their evolution can meet species-specific demands. Furthermore, the conserved functional evolution of Subolesin/Akirin correlates with the protective capacity shown by these proteins in vaccine formulations for the control of different arthropod and pathogen species. These results encourage further research to characterize the structure and function of these proteins, and to develop new vaccine formulations by combining Subolesin/Akirin with interacting proteins for the control of multiple ectoparasite infestations and pathogen infection.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30310 - Parasitology
Result continuities
Project
<a href="/en/project/EF15_003%2F0000495" target="_blank" >EF15_003/0000495: FIT (Pharmacology, Immunotherapy, nanoToxicology)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Physiology
ISSN
1664-042X
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
November
Country of publishing house
CH - SWITZERLAND
Number of pages
17
Pages from-to
1612
UT code for WoS article
000450038800004
EID of the result in the Scopus database
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