Fibrin targeting enable thrombus imaging

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F18%3AN0000095" target="_blank" >RIV/00027162:_____/18:N0000095 - isvavai.cz</a>
Result on the web
<a href="http://www.sci.muni.cz/orion/Setkani/Setkani19/index.htm" target="_blank" >http://www.sci.muni.cz/orion/Setkani/Setkani19/index.htm</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Fibrin targeting enable thrombus imaging
Original language description
XIX. Meeting of Biochemists and Molecular Biologists, Brno, 13.-14. November 2018. Ischemic stroke is leading cause of mortality and morbidity with serious socioeconomic impact. The occlusion blocking the blood flow is formed by a clot. Imaging methods like CTA show brain arteries with flow and arteries without flow are missing. The better imaging methods can lead to more precise treatment such as better targeting of stent retrievers as well as improvement in diagnosis of other thromboembolic events like pulmonary embolism and leg ischemia. As a first step to achieve patients’ clot imaging we employed in vitro models. Simple static models were used for fast screening. Sophisticated flow models mimicking average size of middle cerebral artery were used for selected binders targeting fibrin. The binders were bound to allophykocyanin or liposomes with rhodamin enabling their visualization by microscopy methods.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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