Characterisation of a ST100 Staphylococcus epidermidis producing an LnuB nucleotidyltransferase: Evidence for interspecies spread of an lnuB-carrying transposon

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F18%3AN0000120" target="_blank" >RIV/00027162:_____/18:N0000120 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11140/18:10373306 RIV/00216224:14310/18:00112624

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S2213716518300456?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2213716518300456?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jgar.2018.02.017" target="_blank" >10.1016/j.jgar.2018.02.017</a>

Result language

angličtina

Original language name

Characterisation of a ST100 Staphylococcus epidermidis producing an LnuB nucleotidyltransferase: Evidence for interspecies spread of an lnuB-carrying transposon

Original language description

The increasing emergence of staphylococci resistant to lincosamides is a growing public health concern worldwide. Here, the structure of the first lsaE/lnuB-positive Staphylococcus epidermidis strain isolated in Greece is described. Multilocus sequence typing (MLST) classified the isolate as ST100. Sequence analysis showed that the strain harboured a 12.1-kb segment carrying lnuB and lsaE, flanked by insertion sequence IS257 in parallel orientation. Downstream of the left-hand IS257, four ORFs encoding a hypothetical protein, a putative methyltransferase, an amino-glycoside 6-adenylyltransferase (aadE) and an adenine phosphoribosyltransferase (apt) were found. The apt gene was followed by the spc gene conferring resistance to spectinomycin. A sequence comprising lsaE and lnuB and two ORFs encoding hypothetical proteins of unknown function was adjacent to the right-hand IS257. The lnuB-carrying segment shared extensive similarity (100% coverage, 99% identity) with the IS257-based composite transposon that was identified previously in ST9 methicillin-susceptible and ST398 methicillin-resistant Staphylococcus aureus of human origin. To our knowledge, this is the first description of an lnuB-positive ST100 S. epidermidis worldwide.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30303 - Infectious Diseases

Project

<a href="/en/project/NV17-29239A" target="_blank" >NV17-29239A: Clinical Aspects of Multidrug-Resistant Infections Caused by Gram-negative Bacteria Using a Clinically Relevant Large Mammal Model of Sepsis</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Global Antimicrobial Resistance

ISSN

2213-7165

e-ISSN

2213-7173

Volume of the periodical

13

Issue of the periodical within the volume

Jun

Country of publishing house

GB - UNITED KINGDOM

Number of pages

2

Pages from-to

9-10

UT code for WoS article

000438697700003

EID of the result in the Scopus database

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