Molecular epidemiology of the hepatitis E virus in the Czech Republic

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F18%3AN0000223" target="_blank" >RIV/00027162:_____/18:N0000223 - isvavai.cz</a>

Result on the web

<a href="https://www.visavet.es/data/congresos/hepatitis-e-2018/HEV2018_Hepatitis_E_Workshop_Abstract_Book_01.pdf" target="_blank" >https://www.visavet.es/data/congresos/hepatitis-e-2018/HEV2018_Hepatitis_E_Workshop_Abstract_Book_01.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Molecular epidemiology of the hepatitis E virus in the Czech Republic

Original language description

Hepatitis E: Paradigm of a food-borne zoonotic emerging disease in Europe, 4-5.6.2018. Madrid, Spain - poster. Hepatitis E virus (HEV) is causative agent of an important public health problem worldwide. Although this infection has at least two epidemiological profiles, food-borne transmission of HEV appears to be the major route in European countries. Molecular epidemiology comparing virus sequences derived from human patients and different animal species provides evidence of zoonotic potential and main sources of the virus in Europe; domestic pigs and wild boars. Based on this knowledge, extensive genomic variability among HEV and their known geographical distribution, the objectives of our studies were to perform sequence and phylogenetic analyses of HEV originating from clinical samples of Czech patients with acute hepatitis E, to compare obtained sequences with HEV sequences originating from Czech domestic pigs and wild animals and thus attempt to determine the origin of the infection. Between years 2012 and 2017 a total of 160 partial sequences of HEV ORF1 originating from human patients were analysed. The sequence and phylogenetic analyses showed that 152 HEV sequences belonged to HEV-3. Obtained sequences were phylogenetically related to HEV found in Czech domestic pigs and wild boars or to HEV strains from other European countries. Simultaneously specific geographic distribution of particular HEV strains was observed within the Czech Republic; specific clusters from North Moravia and Central Bohemia. These clusters included HEV found in biological samples of human and animal origin, which supports the hypothesis of interspecies transmission of HEV also in the Czech Republic. During this period of six years, only eight imported HEV infections were identified. HEV-1 was found in clinical samples of seven patients and HEV-4 was detected once. A relationship with the Chinese and Indian HEV strains was revealed. These findings were confirmed by patients' anamnestic data; history of travel to China and India. According to information from the Czech central databases EPIDAT there is significantly increased number of autochthonous in the comparison with imported hepatitis E cases in the Czech Republic; approximately 88 °% of reported cases are of autochthonous origin. Therefore obtained results are in agreement with the national database report.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

30302 - Epidemiology

Project

<a href="/en/project/NV17-31921A" target="_blank" >NV17-31921A: Food-borne viruses - molecular epidemiology and methods for rapid detection</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů