MALDI-TOF MSI method for determining spatial distribution of infection markers in pulmonary tissues of pigs

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F18%3AN0000249" target="_blank" >RIV/00027162:_____/18:N0000249 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43210/18:43914710 RIV/00216305:26620/19:PU131632
Result on the web
<a href="https://mendelnet.cz/artkey/mnt-201801-0103_MALDI-TOF-MSI-method-for-determining-spatial-distribution-of-infection-markers-in-pulmonary-tissues-of-pigs.php?back=/magno/mnt/2018/mn1.php?secid=4" target="_blank" >https://mendelnet.cz/artkey/mnt-201801-0103_MALDI-TOF-MSI-method-for-determining-spatial-distribution-of-infection-markers-in-pulmonary-tissues-of-pigs.php?back=/magno/mnt/2018/mn1.php?secid=4</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
MALDI-TOF MSI method for determining spatial distribution of infection markers in pulmonary tissues of pigs
Original language description
In recent years the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry imaging (MALDI-TOF MSI) is used for molecular mapping of diverse biomarkers such as proteins or peptides in animal/plant tissue sections. It takes full advantage of the benefits of MALDI-TOF technique which is the ability of rapid measurements of all mass spectra in a wide mass range and detection of analytes molecular weights. Interleukins, the group of mostly proinflammatory cytokines, are the proteins that are produced as immune response on bacterial infection Actinobacillus pleuropneumonia. The aim of this study was to develop a MALDI-TOF MSI method for quantitative visualization of spatial distribution of interleukins and other cell markers of lymphocytes, granulocytes and macrophages in porcine tissues of lymph nodes and lungs. The determination of the spatial distribution of produced proteins will bring further useful knowledge of the pathogenesis of this economically important disease of pigs, which can also contribute to reducing the consumption of antimicrobials.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
MendelNet 2018: Proceedings of 25th International PhD Students Conference
ISBN
978-80-7509-597-8
ISSN
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e-ISSN
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Number of pages
6
Pages from-to
495-500
Publisher name
Mendel University in Brno
Place of publication
Brno
Event location
Brno
Event date
Nov 7, 2018
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
000462205300094

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